Collaboration in Research

Early steps towards collaborative research are underway between CONNECT and CAN-BIND at St. Michael’s Hospital

Depression is the leading cause of disability worldwide and concussions are the most prevalent brain injuries. About 20-40% of people experience depression after a concussion. People who experience depression and concussion often face a challenging recovery. It is unclear how the co-occurrence of concussion and depression affects behaviour. A recent report entitled, “Exploring the effect of concussion history on reward processing and anhedonia in depression,”  has engaged two Ontario Brain Institute networks – Concussion Ontario Network (CONNECT) and Canadian Biomarker Integration Network in Depression (CAN-BIND). This study took a novel approach to recruitment of patients who had experienced a concussion, by using the patient registry developed by CONNECT network. Early pilot work from the study suggests a difference in effort and reward learning behaviour in those with depression and a history of concussion compared to those with depression and no history of concussion. A larger study is underway, with the research team continuing to use the patient registry to identify participants who have experienced a concussion. The study will incorporate brain imaging and clinical assessments to gain a more comprehensive understanding of the interaction between concussion and depression. Researchers from both networks will review the study findings. 

For more information about this work please contact, Amanda Ceniti at

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